There were lower PTSD relapse rates in the group that received sertraline (5%) than in the placebo group (26%). All 3 PTSD symptom clusters remained improved in patients who did not relapse, and Kaplan-Meier analyses were consistent with an extended time in remission for the sertraline group. Rapaport and colleagues 4 assessed quality of life (QOL) variables in patients with PTSD who were treated with sertraline over a 64-week treatment period. These data support the notion that continuation and maintenance treatment with sertraline may not only improve symptoms of PTSD and prevent relapse but may also improve associated occupational and social impairment and quality of life. read more

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